Isolation and Identification of Human Renin Inhibitor from Aralia cordata (Udo)
نویسندگان
چکیده
We screened for human renin inhibitory activity in wild vegetables and found the activity in methanol extract of Aralia cordata. Physico-chemical data on the isolated inhibitors were identical to those of (–)-kaur-16-en-19-oic acid (kaurenic acid, KA) and pimaradienoic acids (PDA, 8:2 mixture of pimara-8(14), 15-dien-19-oic acid: pimara-9(11) 15-dien-19-oic acid). KA and PDA also inhibited porcine renin but had nearly no effect on other proteinases. This is the first demonstration of renin inhibitors in wild vegetables.
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